United States securities and exchange commission logo

                 November 15, 2021

       Christine Pellizzari
       General Counsel
       Science 37 Holdings, Inc.
       600 Corporate Pointe, Suite 320
       Culver City, CA 90230

                                                        Re: Science 37
Holdings, Inc.
Statement on Form S-1
                                                            Filed November 5,
                                                            File No. 333-260828

       Dear Ms. Pellizzari:

              This is to advise you that we have not reviewed and will not
review your registration

               Please refer to Rules 460 and 461 regarding requests for
acceleration. We remind you
       that the company and its management are responsible for the accuracy and
adequacy of their
       disclosures, notwithstanding any review, comments, action or absence of
action by the staff.

             Please contact Janice Adeloye at 202-551-3034 or Jennifer
Lopez-Molina at 202-551-
       3792 with any questions.


                 Division of Corporation Finance

                 Office of Trade & Services
       cc:                                              Erika L. Weinberg